Again he has diarrhea and this month he seems agitated or nervous. It sounds as if she's been pinched while sleeping although nothing visible happened. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. Maybe? Soft stools. This drug needs to be pulled off the market! My dog is having seizures. After seeing his condition worsen, that night we took him to an after hours urgent care. Not even going to risk it . Since she is young, the vet started us with Keppra. It is recommended that all pets be tested for existing heartworm infection prior to starting treatment with Simparica Trio. Also feed bland diet- rice, ground beef, chicken, cottage cheese. Instead, it kills larvae, allowing your dog to avoid infection. I returned to vet next day with him and was advised he was ok. thank you. I hope it is better. But im 99% sure the simparica is what caused it. So we went home with her on steroids and more antibiotics and denamrin for liver. Sunday I started watching how much water he was drinking feeling bad that I was restricting him, so I made sure to take him out to pee every few hours. How long do the side effects last? Im so angry at these drug companies and vets for selling this crap. Thank you all so much for this thread and giving me hope. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! I am so mad at the vet and think we should file suit against this company. Really angry this drug is on the market and pushed by many vets. We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. Hi, my dog is having these same issues right now and Im dying. I won't sleep until we all get the justice for our babies that don't have voices of their own. corgi lying in grass next to woman's feet. I am currently in the same situation and we are at day 16 after giving simparica. He seems dehydrated. He woke up and seemed much brighter. Once she is completely healed I am putting her back on those. I've tried Gatorade and Ginger ale but he only drank a little. I just wish I could find a vet who honestly loves my animals as much as I do. Haven't noticed any other symptoms to him besides the puking, not eating and skittish. Never again are my dogs getting oral medication for fleas & ticks. I did some research and because he seemed otherwise fine, I assumed it was "small white dog" shaking due to his breed mix. We rescued another dog. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. Our baby isnt the same at all since his one and only dose of Simparica. We took him to the animal er and they checked his vitals and he was fine. I am sorry you are going through this! Went to a different vet, within minutes he found a large mass on my Poms abdomen. I am taking them both off Simparica. Hi, we did a spinal tap and MRI, its not viral or bacterial, its called steroid responsive meningitis which essentially is the meninges inflaming on their own, but if you look in this thread youll see others reporting similar symptoms/diagnosis so I do think Simparica trio triggered/caused it. She was shaking like she was freezing. Gastrointestinal Issues: Some dogs may experience diarrhea, vomiting, or a decreased appetite after taking Simparica Trio. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Neurologist doesnt seem to really know if the effects are long term or not. He seems back to his normal self and playing with his toys, but we will not continue the following doses! I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. He now cannot go in the car anymore. The neurologist I went to would not give him steroids until I did the spinal tap and MRI. As per the vet, Simparica is an excellent flea and tick product that is available in oral form. I am also going to contact the vet who gave it to me and tell him all this stuff. PetMDs medications content was written and reviewed by veterinary professionals to answer your most common questions about how medications function, their side effects, and what species they are prescribed for. Gave my 14 month old 88 lb. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. Same thing has happened to my 5 month old puppy after taking simparica. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. It's now March 23, he still has falls but not like at first. I'm besides myself. Good bless you all. Im switching back to the old stuff. Vet said "cant be Simparica because he had 9 days ago". 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. I will never give him this drug again. I dont want to have to put my dog down but hes suffering. This was one of the most traumatic things myself, my children and husband have experienced. Thank you in advance. Here is the safety info from the manufacturer Zoetis: SIMPARICA TRIO was administered orally to 8weekold Beagle puppies at doses of 1, 3, and 5X the maximum labeled dose (2.4 mg/kg sarolaner, 48 g/kg moxidectin, and 10 mg/kg pyrantel) at 28 day intervals for 7 treatments. She never did that before! I wish I had read these comments before giving this to my Frenchie. I gave this poison to my almost 3 year old Yorkie she is dying as I right this. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . I'll continue to watch her. Same here! Took to vet and she said it could be the Simparico Trio. All the swelling went down immediately and the itching went away too. Please do NOT use it!! He is otherwise normal and healthy. My aunt gave her 5.5-kg, 13-year-old female shih tzu the first dose of Simparica and she has never been the same as she shows symptoms of cardiopulmonary illness: lethargy, loss of appetite, vomit, coughing, seizure and excessive drinking. and you expect people to give this to their beloved pets? It has been one week and she has been acting very anxious since. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. Simparica has not been evaluated in pregnant, breeding or lactating dogs. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. Simparica and Simparica Trio should be stored at or below 86 F. Brief exposure of Simparica to temperatures up to 104 F are acceptable. Im beside myself. Product (Reports), Deaths/%, Seizures/% Nexgard 18. We did get a little symptom improvement from prednisone if they are having other neurological issues. In very rare instances, mild side effects and irritations can occur for a short period of time. The results are fatal for fleas and ticks but safe for mammals such as your dog. I wish I could get it out of her system. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I just almost had a similar incident with my 16wk cavapoo. Lost all appetite. I gave my dog his first dose April 8th. Would appreciate any opinion you all may have. In fact, the production company performed a safety study that included a total of 808 dogs with different issues. Seizures continue and its Monday. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. Work up from the neurologist shows all his tests came back negative. This is lethal medication for dogs and should be taken off the market now. I'm so sorry. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . My dog has had 3 seizures in the past from wearing a flea collar. In such cases, please visit the veterinarian as soon as possible. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. I am devastated. Over time, I spent 7k to save here but to no avail. No problem eating. Never any issues with bravecto so we'll return to that medication. This is terrible. I feel like I have been poisoning my puppy for months at this point. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. How common are Simparica side effects? The same thing possibly is happening to my 9 month old Boxador. She spent 4 nights at the University of Auburn emergency room and vet clinic. She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. Banfield Hospital pushed" Simparica Trio" on our 16 year old Toy Poodle which caused a neurological disorder of sundowner to the point of him having two days straight of constant seizures, repetitive pacing and extreme agitation. I have had German Shepherds for 40 yrs. I went to banfield hospital and they prescribed this medication for my dog and had thrown up non stop since he was given the pill and wouldnt eat anything and he passed away 10 days later (yesterday). She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. We hope this will solve our problems and he can live a healthy and happy life. It's unique because it kills more types of parasites than any other combination product available to date. I notified my vet and Zoetis, the company that makes this drug. He would come out of it when I shook him, so I didn't think anything of it at the time. Those jaw spasms have decreased but were pretty alarming in Dec and January. She's been fine since. My best friend's new puppy has had diarrhea for 14 days after taking one dose of Simparica. This past October he just wasn't the same. What You Need to Know About the Lyme Vaccine for Dogs. Itching has decreased immensely. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. I am SOOO angry! They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. She also started with ear infections. We were so upset - I vowed to never use oral flea treatment again. Thank you for giving information on what happened to your dog. How is your dog doing? They could either keep her there for observation or I could take her home to observe her. The most common side effects of Simparica Trio include vomiting and diarrhea. The exact same thing is happening to my dog now. After about a week, she started to improve. He hasn't eaten since and grazes on grass like he is a goat. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. My sweet, funny, smart as can be baby girl died on 9/26/20. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. This sure seems like this happening way too often . I hope yours is an isolated incident! My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. If you're not already protecting your dog from common disease-causing parasites, then it's time to schedule a visit to your veterinarian. I lost my girl 2 days after taking Simparica. I gave him this medication last Thursday. I thought right away it must be the new meds! The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Copyright 2023 Meredith Corporation. How is your dog doing at this time? She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. Does anyone know of anything we can give her to help get this out of her system? Vet prescribed this for my 12 week old border collie Lab mix. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. I feel like she's been an experiment to make others money. Did you ever do an MRI or spinal tap? org to have this poison recalled. They are monitoring her. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. He also lashes at me with his teeth. This is whats happening to our pup, can you please tell me how long it lasted? 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